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First, the ligand-binding pocket is split into two distinct regions, forming a bifurcated pocket. Within this pocket, a salt bridge between Glu124 3.33 and Arg283 6.55 [superscripts denote the BallesterosWeinstein numbering system (Figure 2B)

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Vegans and vegetarians may require supplementation, as plant-based foods contain negligible B12 unless fortified

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